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Next Generation Sequencing: benefit analysis to support a strategic adoption model in the Italian NHS

Authors

  • Marco Volpe

    Director

  • Jean Marie Franzini

    Director

The evolution of tumor genomic profiling in personalized medicine requires a strategic management of genetic testing. Among the available technologies, Next Generation Sequencing (NGS), allows simultaneous testing for a wide range of genes. However NGS test benefits still need to be assessed and compared to the single-gene test (SGT) approach to provide recommendations for a strategic adoption in the Italian NHS setting.

The study aims to assess the differential impact of NGS and single-gene tests on the diagnostic-therapeutic process of patients with advanced non-small-cell lung cancer (aNSCLC) in a selection of Italian hospitals. On this purpose, we designed a decision model structured in two arms, SGT and NGS approaches, and three stages i.e. diagnostic biopsy, genetic testing and therapy initiation.

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